Associate Scientist, Analytical Development

Formulation and Analytical Development · Cambridge, Massachusetts
Department Formulation and Analytical Development
Employment Type Full-Time

The Company

Verve Therapeutics is a biotechnology company created with a singular focus: to protect the world from heart disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, the company aims to develop transformative, once-and-done therapies for coronary heart disease. Verve’s gene editing medicines are designed to safely edit the genome of adults and mimic naturally occurring gene variants to permanently lower LDL cholesterol and triglyceride levels. The company is advancing a pipeline of precision genetic medicines, led by VERVE-101, which is being developed initially for heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease. In 2021, Verve was selected as a Top Places to Work by The Boston Globe and Best Places to Work by the Boston Business Journal. Verve is headquartered in Cambridge, Massachusetts.

The Position


Verve is seeking Associate Scientist in Analytical Development to support analytical method development and testing of oligonucleotide drug substance and drug product. This individual will be involved across development stages in developing analytical and bioanalytical methods for mRNA and guide RNA characterization. The successful candidate will be responsible for executing analytical methods from lab scale to preclinical development and interpreting data. The scientist in this position will be part of an integrated R&D project team that aims to advance preclinical gene editing candidates into the clinic. This is a hands-on role.


  • The candidate will be responsible for the maintenance and operation of a broad range of analytical instrumentation, including U/HPLC, capillary electrophoresis, DSC, AF4-MALS, DLS and UV-spectrophotometry.
  • This position will support analysis of samples from process development teams for a variety of substances, including small molecules, large oligonucleotides, and lipid nanoparticles.
  • The candidate will be responsible for generating and updating protocols for analytical test methods, writing method development summaries and preparing presentations for cross-functional discussions.


Skills and Qualifications

  • Candidates should have proven experience in analytical U/HPLC, capillary electrophoresis, quality control processes and hand-on experience with state-of-the-art analytical instruments.
  • Knowledge/hands-on experience in analytical method development and biotechnology processes preferred. Specific experience with oligonucleotides and/lipid nanoparticles is preferred but not required.
  • Ideal candidates would have experience in the validation of analytical assays according to ICH guidance, to ensure their robust performance.
  • Candidates should have earned a bachelors degree in chemistry, analytical chemistry, biochemistry, pharmacy or related area and should have 5+ years experience in a biotech laboratory setting.


EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.

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  • Location
    Cambridge, Massachusetts
  • Department
    Formulation and Analytical Development
  • Employment Type