Associate Director, Biophysical Characterization

Formulation and Analytical Development · Cambridge, Massachusetts
Department Formulation and Analytical Development
Employment Type Full-Time

The Company

Verve Therapeutics is a biotechnology company created with a singular focus: to protect the world from heart disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, the company aims to develop transformative, once-and-done therapies for coronary heart disease. Verve’s gene editing medicines are designed to safely edit the genome of adults and mimic naturally occurring gene variants to permanently lower LDL cholesterol and triglyceride levels. The company is advancing a pipeline of precision genetic medicines, led by VERVE-101, which is being developed initially for heterozygous familial hypercholesterolemia, a potentially fatal genetic heart disease. In 2021, Verve was selected as a Top Places to Work by The Boston Globe and Best Places to Work by the Boston Business Journal. Verve is headquartered in Cambridge, Massachusetts.


The Position

  • Verve is seeking an experienced Associate Director, Biophysical Characterization within its Analytical Development to lead a team in implementing new biophysical and separations methods and technologies to characterize mRNA, gRNA and LNP-encapsulated gRNA and mRNA. This individual will be leading a cross-discipline team to design, develop and qualify phase appropriate analytical methods to support Verve’s growing gene editing pipeline.
  • The position will be part of an integrated R&D team that aims to advance preclinical gene editing candidates into the clinic and work closely with discovery, process development and internal quality control group.

 

Responsibilities

  • Provide technical expertise for the structural characterization of gRNAs, mRNAs and lipid nanoparticle (LNP) complexes
  • Work across the AD team and cross-functionally to lead, plan, and execute complex characterization studies; serve as the analytical lead in cross-functional interactions
  • Develop and implement methods intended for a variety of purposes, including release and stability testing, product characterization, and high throughput analysis
  • Serve as analytical lead for CMC project teams
  • Oversee troubleshooting, tech transfer, and phase-appropriate validation of analytical methods at contract testing labs
  • Demonstrated competency in operating HPLC/UPLC/LC-MS instrumentation
  • Conceptual understanding of solid phase oligonucleotide synthesis and purification strategies.
  • Must have hands-on experience analyzing DNA/RNA by IP-RP, IEX, LC-fluor and multi-modal LC techniques.
  • Must have hands on experience analyzing RNA by biophysical techniques such as DSC, CGE, UV thermal analysis, qPCR, RT-PCR etc.
  • Author and review technical reportsand regulatory submissions
  • Train and mentor junior team members
  • Oversee a vibrant team working on mRNA and guide RNA biochemical assays
  • Knowledge/hands-on experience in oligonucleotide lipid nanoparticle delivery, production and purification short and large oligonucleotides, protein engineering and process development are a plus, but not required.
  • Candidates should have an advanced degree in Chemistry, Biophysics, Biochemistry, Bioengineering, or related life sciences field with strong scientific background and 7+ years’ relevant experience


EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.


Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.


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  • Location
    Cambridge, Massachusetts
  • Department
    Formulation and Analytical Development
  • Employment Type
    Full-Time